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Chondrosarcoma treatment Guidelines

ESMO-PaedCan-EURACAN guidelines recommend that low-grade central chondrosarcomas in the long bones of the limbs be managed by curettage, with or without adjuvant therapy (eg, phenol, cement,..

mesenchymal chondrosarcoma may receive multiagent chemotherapy similar to Ewing's sarcoma It may be feasible to safely treat extremity grade I (low grade) chondrosarcoma with intralesional curettage without increasing the risk for local recurrence or metastatic diseas Guidelines for treatment of chondrosarcoma have been developed by the National Comprehensive Cancer Network (NCCN) [ 25] and jointly by the European Society for Medical Oncology (ESMO), the..

Chondrosarcoma is the rarest bone cancer, primarily affecting adults older than 40 years. Survival rates are higher because most of these tumors are low-grade lesions Most oncologists will recommend surgery, chemotherapy and radiation therapy if they are possible for all patients with mesenchymal chondrosarcoma (Platania, Kruse, La Spina, Antonio, Tuncer, and Huvos). Most physicians recommend an initial chemotherapy strategy similar to Ewing's sarcoma and other soft tissue sarcomas

Chondrosarcoma Guidelines: NCCN and ESMO-PaedCan-EURACAN

Surgery is the main treatment for most types of chondrosarcoma. It may be used for tumours that are newly diagnosed and tumours that come back (recur). The following types of surgery may be used. Wide resection removes the bone tumour and a wide margin of normal bone and tissue around the tumour Dedifferentiated chondrosarcoma is often treated like osteosarcoma, with chemo being given first, followed by surgery and then more chemo. Mesenchymal chondrosarcomas are often treated the same way as Ewing tumors (Ewing sarcomas). Treatment typically includes chemo, surgery, and radiation therapy The role of dose escalation and proton therapy in perioperative or definitive treatment of chondrosarcoma and chordoma: An analysis of the National Cancer Data Base. Cancer 2019; 125:642. Wyman JJ, Hornstein AM, Meitner PA, et al. Multidrug resistance-1 and p-glycoprotein in human chondrosarcoma cell lines: expression correlates with decreased. • Surgery is mainstay of treatment • Mesenchymal chondrosarcoma responds to CT/RT 19/04/18 23 Thank You • UK guidelines for the management of bone sarcomas, Gerrand et al. Clin Sarcoma Res (2016) 6:7 • Campbells 13th edion, 201

Chondrosarcoma low-grade 1 | Flickr

The NCCN Guidelines for Bone Cancer focus on chordoma, chondrosarcoma, Ewing sarcoma, and osteosarcoma. The guidelines also provide recommendations for treating giant cell tumor of bone (GCTB). Although typically benign, GCTB is locally aggressive and can lead to significant bone destruction Gerrand et al. Clin Sarcoma Res DOI 10.1186/s13569-016-0047-1 REVIEW UK guidelines for the management of bone sarcomas Craig Gerrand1*, Nick Athanasou2, Bernadette Brennan3, Robert Grimer4, Ian Judson5, Bruce Morland6, David Peake7, Beatrice Seddon8, Jeremy Whelan 8 and On behalf of the British Sarcoma Group Abstract This document is an update of the British Sarcoma Group guidelines published. Bone sarcomas: ESMO-PaedCan-EURACAN: Clinical Practice Guidelines for diagnosis, treatment and follow-up. Published in 2018 - Ann Oncol (2018) 29 (Suppl 4): iv79-iv95. The 2018 ESMO Clinical Practice Guidelines on bone sarcomas have been produced by ESMO in partnership with EURACAN (European Reference Network for Rare Adult Solid. Complete surgical removal of the tumor, along with a wide margin of healthy tissue, has historically been the preferred treatment of chondrosarcoma. Limb salvage surgery is a common treatment technique, and amputation is only used occasionally for advanced or recurrent disease Current guidelines suggest that patients with mesenchymal chondromas should be treated with Ewing sarcoma regimens and that patients with dedifferentiated chondrosarcoma should be treated with osteosarcoma regimens. Additionally, sirolimus and cyclophosphamide could be considered for systemic recurrence in high-grade chondrosarcoma

The goal for treatment of chondrosarcoma is to remove the mass and reduce the likelihood that it will return. Close follow-up with your healthcare provider may be necessary INTRODUCTION. Chondrosarcomas are a heterogeneous group of malignant bone tumors that share in common the production of chondroid (cartilaginous) matrix [ 1 ]. Chondrosarcomas are the third most common primary malignancy of bone after myeloma and osteosarcoma [ 2 ]

The treatment recommendations you find here were developed by the Chordoma Global Consensus Group A multidisciplinary, international group of over 60 doctors who have extensive experience caring for chordoma patients. The group is responsible for developing and publishing consensus guidelines, based on all available medical and scientific evidence, for the treatment of primary and recurrent. These guidelines are an attempt to review current evi-dence concerning soft-tissue sarcoma diagnosis and treatment, and provide recommendations to support best practice. They are not intended to be prescriptive, but aim to improve the quality of care for patients with STS by helping identify and inform the key decisions involved in their. This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommendations by the European Society of Medical Oncology, The National Comprehensive Cancer Network and The National Institute for Health and Care Excellence have been incorporated, and the. Osteosarcoma (OS), chondrosarcoma, and chordoma are characterized by multiple challenges to the investigator, clinician, and patient. One consequence of their rarity among sarcomas, as well as their biologic and clinical heterogeneity, is that management guidelines are inadequate to inform the range of individual patient-treatment decisions from diagnosis, approaches to surgery, chemotherapy. Chondrosarcoma arising in monostotic fibrous dysplasia is very rare. • Wide surgical margin provides good local control, thus become the mainstay treatment of chondrosarcoma. • Limb salvage surgery in chondrosarcoma provides good functional outcome

A Mayo Clinic surgeon explains treatment options to a patient. Because chondrosarcoma is uncommon, not all doctors are experienced in treating this form of cancer. Mayo Clinic maintains a dedicated sarcoma team that treats chondrosarcoma and related conditions. Over the decades, Mayo Clinic has treated more than 1,000 people with chondrosarcoma Chondrosarcoma Treatment The treatment of the disease depends on a number of factors such as the stage, location and size of the tumor as well as the age and the overall health of the patient. There are different treatment options available for the condition Surgery is the standard treatment for chondrosarcoma. The surgeon removes the tumor along with some surrounding healthy tissue. Surgical options for chondrosarcoma include biopsy (described above), limb-sparing surgery, and amputation. The best procedure for you will be determined by the cancer's stage and location This can help guide treatment decisions. While imaging tests will be performed as part of a chondrosarcoma diagnosis, a biopsy is necessary to confirm whether it is cancerous. There are two categories of biopsy: needle and surgical. During a needle biopsy, the doctor extracts a small sample of the spinal chondrosarcoma tumor with a hollow needle

What are the treatment guidelines for chondrosarcoma

Introduction. Dedifferentiated chondrosarcoma is defined as a cartilaginous neoplasm characterized histologically by islands of benign or low-grade chondroid tumors adjacent to components of nonchondroid high-grade sarcoma [4, 16, 20].Treatment of dedifferentiated chondrosarcoma remains a major challenge Find out about the symptoms, causes, and treatment of chondrosarcoma, a type of bone cancer most common in your pelvis, thighbone, or upper arm Chondrosarcoma Support Groups. A number of forums and foundations have been established to provide information and treatment guidelines to help patients fight the condition. The most notable among these include: Sarcoma Foundation of America. 9884 Main Street. Damascus, MD 20872. USA. Tel: (301)253-8687. Fax: (301)253-8690. Email: mailto:info. Canine Chondrosarcoma treatment tends to be necessary in dogs 1 - 12 years of age or older and is not as severe as the more common Osteosarcoma. Chondrosarcoma accounts for 10% of dog bone cancers. The cancer is found in the pelvis area, bones around the nose, and the rib area. The tumor grows in the bone cartilage (cartilage connects the bones. Dramatic improvements in survival have been achieved for children and adolescents with cancer. [ 1] Between 1975 and 2010, childhood cancer mortality decreased by more than 50%. [ 1] For Ewing sarcoma, the 5-year survival rate has increased over the same time from 59% to 78% for children younger than 15 years and from 20% to 60% for adolescents.

Chondrosarcoma Treatment & Management: Approach

chondrosarcoma. The patient declined proposed adjuvant chemotherapy and underwent multiple resections for rapid local reoccurrence. He ultimately elected for hospice care. Conclusion: The case highlights the importance of close disease monitoring and exploration of treatment options, given lack of established guidelines and consistent tumor. Blue tegus (Salvator merianae) are a lizard species belonging to the family Teiidae, a subspecies of the Argentine black and white tegu.Adult Argentine black and white tegus can reach about 130 cm in length, and are native to South America [].The prevalence of neoplasms in reptiles has been reported to be nearly equal to that in mammals [3, 5], and the prevalence of neoplasms is reportedly. Chondrosarcoma is one of the most common malignant bone tumors in adults. Conventional chondrosarcoma represents around 85% of all chondrosarcomas and is notoriously difficult to treat with chemotherapy. We describe a 67-year-old man with metastatic conventional chondrosarcoma who was treated with nivolumab. Treatment was discontinued after restaging showed increased tumor burden, which later. Death from disease, transformation of a low-grade chondrosarcoma to a dedifferentiated chondrosarcoma, or the development of metastatic disease were considered adverse outcomes. RESULTS The 109 patients who met the study criteria included 60 males and 49 females ranging in age from 17 to 83 years (mean, 50 years) (Table 1)

Bone Cancer: Diagnosis and Treatment Principles - American

Mesenchymal Chondrosarcoma Treatment, Support and Researc

1 INTRODUCTION. Chondrosarcoma (CS) is a group of cartilage-forming tumors. It accounts for 20-27% of primary malignant bone neoplasms. 1 The most common anatomical location of this cancer is the pelvis, followed by the proximal femur, proximal humerus, distal femur, and ribs. 2 Most CS patients suffer pain, swelling, and the presence of a mass of variable duration. 3 It is intrinsically. A total of 6 patients will be enrolled in this run-in phase 1b. Patients will be followed post operatively as per NCCN guidelines with local and systemic imaging. Expansion Cohort: The phase 1b expansion cohort of the study will provide an estimate of the relative treatment effect of zoledronic acid on any grade chondrosarcoma specimens Chondrosarcoma is the second most common primary bone tumor in the dog, accounting for 5-10% of primary bone tumors in dogs. The most commonly affected site is the nasal cavity, although the ribs, pelvis, long bones of the limbs, and non-skeletal sites have also been reported to be involved. Chondrosarcoma is most commonly seen in middle-aged.

The guidelines on bone cancer were released on October 3, 2018 by ESMO, PaedCan, and EURACAN. [Diagnosis and Pathology/Molecular Biology . Management of bone sarcomas should be carried out in a reference center for bone sarcomas, with a primary biopsy under the supervision of a surgical team or dedicated interventional radiologist ferentiated chondrosarcoma is treated as osteosarcoma. [1] Current guidelines of the National Comprehensive Cancer Network (NCCN, version 1.2018) indicate that conventional chondrosarcoma (Grades 1-3) has no known standard chemotherapy options. Any efficacious systemic treatment would expand our current arma-mentarium for this difficult. 11520066 10.1006/bbrc.2001.5411 15 Pollack SM Li Y Blaisdell MJ: NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine. PLoS One. 2012; 7 (2): e32165 A single cancer treatment is difficult enough for patients to endure. Undergoing multiple forms of treatment simultaneously or in close progression can be severely disabling. This is the reason the SSA has recently approved Chondrosarcoma with Multimode Therapy for expedited processing under the Compassionate Allowances program

Treatments for chondrosarcoma - Canadian Cancer Societ

Treating Specific Bone Cancers - American Cancer Societ

Chondrosarcoma - UpToDat

  1. Sustainable Investing; Advisor Insights; Personal Finance; Market Volatility; Retirement Planning; Start Investing; Save for College; See Al
  2. Chondrosarcoma is a malignant growth arising in chondrocytes. There are two types of chondrosarcomas, either primary or secondary. Primary chondrosarcomas arise in areas of previously normal bone that are derived from cartilage. Secondary chondrosarcomas are lesions produced from pre-existing cartilage lesions
  3. Chondrosarcomas (CHS) represent a heterogeneous group of disorders ranging from indolent, low-grade tumors to aggressive, high-grade forms. Surgical resection represents the primary and preferred treatment modality for individuals with localized disease. Radiation therapy is appropriate for the treatment of positive surgical margins or palliation of disease-related symptoms
  4. Call 434.924.9333. Chondrosarcoma grows in bone cartilage. Cartilage cushions your joints and supports your bones. This kind of bone cancer shows up as a tumor in your femur, arm, pelvis, knee, and spine. Treatment usually means surgery to remove the tumor
Symptoms and Complications of Paget's Disease of Bone (18

NCCN Guidelines Insights: Bone Cancer, Version 2

Wide surgical resection is the treatment of choice [1, 5, 6, 9, 10, 12]. Local recurrence is associated with incomplete excision . Before surgery, it is essential to establish whether the tumor involves the medullary cavity. In case of medullary involvement, the tumor should be treated as a central chondrosarcoma ObjectiveTo evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) for chordoma and chondrosarcoma.MethodsTwenty consecutive patients with a histopathologic diagnosis of chordoma (n = 16) or chondrosarcoma (n = 4) treated between 2010 and 2016 were retrospectively identified. All patients underwent FSRT in five fractions to a median dose of 37.5 Gy (range: 25-40. Regarding treatment, complete surgical resection of the tumor is recommended as malignant cartilage may be observed with mixed epithelial/mesenchymal neoplasms. Complete resection of the tumor may also prevent misdiagnosis based on improper biopsy specimen as teratomas may resemble pulmonary chondrosarcoma from biopsy location inaccuracy

Bone Sarcomas ESM

Current guidelines of the National Comprehensive Cancer Network (NCCN, version 1.2018) indicate that conventional chondrosarcoma (Grades 1-3) has no known standard chemotherapy options. Any efficacious systemic treatment would expand our current armamentarium for this difficult disease A case of chondrosarcoma arising in the cerebellum after radiation treatment for an astrocytoma has been reported . There is a marked predeliction for cranial chondrosarcomas to occur in the skull base, particularly in the sphenoid bone or clivus . This is thought to be due to the endochondral ossification that occurs at this site and to the.

Mesenchymal chondrosarcoma is a rare, high-grade malignancy of bone or soft tissue first described by Lichtenstein and Bernstein1 in 1959. It represents only 2% to 10% of all chondrosarcomas2-7 and has a frequency of 0.2 to 0.7 cases per 100 000.8 Based on this information, the extrapolated incidence is less than 215 cases per year in the United States Conventional chondrosarcoma tumors are generally considered to be resistant to conventional chemotherapy and radiotherapy; thus, surgery with adequate margins is the treatment of choice. 6 Outcomes are generally good for patients treated surgically with wide margins, but survival can be negatively affected by factors such as a high histologic.

title = Bone cancer, version 2.2017 featured updates to the NCCN guidelines, abstract = The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline. • chondrosarcoma of skull base, account for 0.1% of intracranial tumors This document is intended for use by members of the Central Nervous System site group of the Princess Margaret Hospital/University Health Network. The guidelines in this document are meant as a guide only, and are not meant to be prescriptive The goal for treatment of chondrosarcoma is to remove the tumor and reduce the chance that it will return. Close follow-up with your healthcare provider is needed. And tests will be done during treatment to see how well it's working. Your treatment options may include: Surgery. This is the most common treatment for chondrosarcoma

Judith BOVEE | Professor | MD PhD | Leiden UniversityFatal case of Chondrosarcoma of maxilla

Chondrosarcoma Cancer: Symptoms, Treatment, Research & Suppor

  1. Nearly 26% of chondrosarcoma cases in cats involve the flat bones. The flat bones include the bones of the skull, as well as the ribs, sternum, pelvis, and scapula (shoulder blade). Clinical signs associated with chondrosarcoma at these sites will vary depending on the location of the tumor. You may notice a visible swelling or localized pain.
  2. Testicular chondrosarcoma Abdulaziz Alhussaini 1, Mohammed Al Mansour 2, Noura Al Oudah 3, Khalid Al Rabeeah 4, Abdullah Al Khayal 4, Saad Abumelha 4 1 College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia 2 Division of Urology, Security Forces Hospital, Riyadh, Saudi Arabia 3 Department of Pathology and Laboratory Medicine, Ministry of the National.
  3. ed, with a focus on identification of prognostic factors
  4. coma, chondrosarcoma, chordoma, giant cell tumor of bone and other rare bone tumors is reviewed in this guideline. Ewing's sarcoma will be the focus of a separate guideline because of its specific biological, clinical and therapeutic features. Each statement has been accompanied by the leve
  5. Guidelines ESMO. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. PubMed; NCCN. NCCN Guidelines - Bone Cancer; Chondrosarcoma, all lines of therapy. No standard chemotherapy for grades 1 to 3 conventional chondrosarcoma; Mesenchymal chondrosarcoma has been treated with Ewing's sarcoma regimen
  6. To our knowledge this is the first systematic review of tracheal chondrosarcoma treatment outcomes. Management insights are thoroughly discussed. Men constitute 93.8% of cases, and most of these occur in the distal trachea. The most common symptom, dyspnea, occurs in virtually all patients. Extratracheal extension had occurred in 78.6% of patients
  7. Once chondrosarcoma has been diagnosed, you have options for treatment including: Surgery. This is the most common treatment for chondrosarcoma. If the chondrosarcoma is located in a limb, a procedure will be done to attempt removing the sarcoma without the limb. In some cases, amputation may be necessary. Radiation Therapy
Sarcoma Research - International | Open Access JournalsProstate cancer Archives - BJUI

Chemotherapy for Bone Sarcoma in Adults JCO Oncology

Radiographically, the typical chondrosarcoma has a malignant appearance consisting of poor margination, cortical destruction, and soft-tissue extension. Calcified matrix is present in about two-third of patients. The treatment advocated by both groups is en bloc resection, if possible. Local recurrence was found to be diminished with en bloc. To investigate the clinical, imaging and pathological features of dedifferentiated chondrosarcoma for better diagnosis. Patients who had been confirmed to have dedifferentiated chondrosarcoma were enrolled in this study and analyzed in the clinical, imaging and pathological data. Twenty-five patients had pathologically confirmed dedifferentiated chondrosarcoma including 15 males and 10 females. We help you find an expert for your disease. All doctors and clinics listed here have been checked by us for their outstanding specialization in the area of Chondrosarcoma. They await your inquiry or treatment request

Osteosarcoma by vikrant - Issuu

Chondrosarcoma Johns Hopkins Medicin

Background Chondrosarcoma is the second most frequent malignant bone tumor. Grade I chondrosarcoma (syn.: atypical cartilaginous tumor) is classified as an intermediately and locally aggressive neoplasm and typically is treated less aggressively (i.e., by intralesional curettage). Does the data regarding local recurrence (LR) and metastatic disease justify this? Methods From 1982 to 2014, 37. Primary mesenchymal chondrosarcoma of the kidney is an extremely rare malignant tumor. To our best knowledge, only 9 such cases have been reported so far. In the current paper, we present the case of a 67 year-old patient with recurrent left lumbar pain, increased fatigability and intermittent macroscopic hematuria. He underwent a surgical resection of the left kidney and left hemicolon Kondziolka et al. reported the use of gamma knife stereotactic radiosurgery in 6 patients, 4 with chordoma and 2 with chondrosarcoma of the skull base, as an adjuvant treatment in 5, and as the primary treatment in 1. All of the tumors were less than 30 mm in diameter and at least 5 mm from the optic nerve or from the chiasm Chondrosarcoma is a malignant neoplasm that predominantly is made of cartilage. It occurs most frequently in long bones, the pelvic girdle and the scapula. Chondrosarcoma is the second most frequent primary malignant tumor of bone. Chondrosarcoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis

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  1. Osteochondroma. An osteochondroma is a benign (noncancerous) tumor that develops during childhood or adolescence. It is an abnormal growth that forms on the surface of a bone near the growth plate. Growth plates are areas of developing cartilage tissue near the ends of long bones in children. Bone growth occurs from the growth plate, and when a.
  2. Chondrosarcoma (CS) most commonly involves the pelvis. This study aimed to analyze differences in clinical characteristics and prognostic factors between primary and secondary conventional pelvic CS, and provide reference for clinical diagnosis and treatment. Eighty patients (54 primary cases and 26 secondary cases) with pelvic CS were included in this retrospective study
  3. Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patterns of recurrence and correlate LR with a detailed dosimetric analysis. 222 patients were treated with proton radiotherapy for chordoma (n = 151) and chondrosarcoma (n = 71) at the PSI.

Treatment guidelines for newly diagnosed chordoma

  1. Purpose To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiation therapy. Methods Between 6/2014 and 7/2018, a total of 91 patients were treated in our Center. The median age was 38 (range, 4-70) years. Forty-six (50.5%) patients were.
  2. The second case was reported by Yalçinkaya for a patient with testicular chondrosarcoma with no metastasis who was managed by radical orchiectomy. In both formerly reported cases, a remission of 24 months was achieved. Owing to rarity of such cases, well-established treatment guidelines are lacking
  3. The standard treatment for primary, localised extraskeletal myxoid chondrosarcoma is surgery, but patients with advanced disease need medical treatment with drugs. Anthracycline-based chemotherapy, which is the first-line regimen used in soft-tissue sarcoma, has low activity in this sarcoma subtype
  4. Background Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. There are many confusing issues concerning the imaging feature that can facilitate early diagnosis and the factors that might be related to outcomes. Methods Twenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015

UK guidelines for the management of bone sarcomas

Treatment The patient was treated with intravenous immunoglobulins (IVIG) at 0.4 g/kg/d for 5 days without clinical response. Because of the rapidly deteriorating neurologic status, it was decided to start chemotherapy using etoposide at 165 mg/m 2 and cisplatin at 50 mg/m 2 for presumed extragonadal seminoma, followed by 2 additional days of IVIG The average Musculoskeletal Tumor Society score among all 21 patients was 95% (84-100). The combination of intralesional curettage, application of high-speed burring, thermal cauterization, and cementation is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones The prognosis of lung metastasis (LM) in patients with chondrosarcoma was poor. The aim of this study was to construct a prognostic nomogram to predict the risk of LM, which was imperative and helpful for clinical diagnosis and treatment. Data of all chondrosarcoma patients diagnosed between 2010 and 2016 was queried from the Surveillance, Epidemiology, and End Results (SEER) database

Osteosarcoma, Chondrosarcoma, and Chordoma Journal of

Differentiation between central chondroid tumors is important because surgical treatment is the only curative management for patients with grade I chondrosarcoma Chondrosarcoma is a slow growing malignant cancer which can sometimes be found on the larynx or trachea in dogs. Early diagnosis and removal of cancerous tissue results in the best prognosis for this disease Background: Primary intracranial malignancies with extra-skeletal myxoid chondrosarcoma (EMC) features are extremely rare. EMC constitutes a distinct genomic entity characterised by reciprocal translocation of fusion genes, most commonly EWS RNA Binding Protein 1 (EWSR1) in 22q12 with Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) in 9q2-q31.1

Mesenchymal chondrosarcoma of maxilla in paediatric patient. Chondrosarcoma (CS) is a malignant tumour of long and flat bone characterised by the formation of cartilage. Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy Laryngeal chondrosarcoma is an uncommon entity with unknown etiology. Thyroid localization is rare. Diagnosis is difficult. Treatment is exclusively based on surgical excision, requiring a large surgery, sometimes mutilating. Metastasis, correlated with the tumor differentiation degree, are not exceptional. Reference Conventional chondrosarcoma, as the vast majority of chondrosarcomas, poorly responds to chemotherapy and radiation treatment, which results in high morbidity and mortality rates. 1 Recent discoveries in the biology, genetics and epigenetics of chondrosarcoma have significantly advanced our understanding of the pathobiology of chondrosarcoma. As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows an increase in SOX9 expression in chondrosarcoma compared to normal cartilage. Case . A 57-year-old man presenting with two months of insidious shoulder pain was found to have a large thoracic chondrosarcoma invading the spinal canal. The patient's orthopedic oncologist organized an interdisciplinary team including interventional radiology, thoracic surgery, neurosurgery, and plastic surgery. This allowed safe, en bloc tumor resection Tumor lacks bone/cartilage and consists of numerous osteoclast-type giant cells. Giant cell tumor clinical features. Typically near knee joints and can cause arthritis-like symptoms. Treated with curettage but 40-60% recur locally. 4% metastasize to lungs, but can spontaneously regress, seldom fatal